Immunosuppressive agents in multiple sclerosis

Immunosuppressive therapy reduces axonal damage in progressive multiple sclerosis.

BACKGROUND In progressive multiple sclerosis (PMS), disease-modifying therapies have not been shown to reduce disability progression. OBJECTIVE The impact from immunosuppressive therapy in PMS was explored by analyzing cerebrospinal fluid (CSF) biomarkers of axonal damage (neurofilament light protein, NFL), astrogliosis (glial fibrillary acidic protein, GFAP), and B-cell regulation (CXCL13). ...

Infective Agents and Multiple Sclerosis.

Although the pathogenesis of multiple sclerosis remains obscure, much pathological and clinical evidence suggests an infective agent as a possible aetiological factor. If such an agent is responsible for initiating the disease it seems probable that there is a latent period of several years before the development of clinical features of multiple sclerosis. By that time it might be impossible to...

Medicinal Plants as Immunosuppressive Agents in Traditional Iranian Medicine

Multiple Sclerosis in Iran

Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system (CNS). This highlydisabling disorder is characterized by a variable clinical course. MS is a heterogeneous disease with acomplex pathology and significant social and economic impact. MS is associated with dysfunction ofparts of the nervous system which results in a range of signs and symptoms, ...

Systematic review: Superparamagnetic Iron Oxide nanoparticles as contrast agents in diagnosis of multiple sclerosis

Several MRI contrast agents (CAs) are used in medical diagnosis that gadolinium (Gd3+) is the most widely used as contrast agents. Unfortunately, its toxicity is due to its inefficiency. In this review, we discuss about the ability of SPIONs in MRI and application in Multiple Sclerosis diagnosis. Superparamagnetic iron oxide nanoparticles (SPIONs) such as magnetite nanoparticles are used as goo...